Best 11 Supplements for Fibromyalgia Of 2024




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Fibromyalgia is a chronic condition that results in muscle, nerve, and bone pain throughout the body. It usually affects specific parts of the body more severely than others and can cause sudden flare-ups. 

Using NSAIDS and other prescription drugs is not always a choice, especially when intensive and long-term use is needed. Such oral painkillers often come with severe side effects and a risk of addiction. 

Supplements for Fibromyalgia

Fortunately, natural and chemical-free supplements can also deliver the same soothing results without the heft price tag and risk of dependence. 

Here is a related article that might interest you on the Best 19 Creams for Fibromyalgia Of 2024.

The supplements below are carefully selected and chosen for their ability to provide relief from a wide range of fibromyalgia symptoms, including swelling, tenderness, and nerve pain. With a focus on delivering variety, the list includes a diverse range of supplements suitable for different types and severity of Fibromyalgia. 

List of 11 Best Supplements for Fibromyalgia 

There are some wonderful options in supplements for fibromyalgia. Let’s have a look. 

1. MegaFood

The Megafood supplement comes with turmeric as its main ingredient. Turmeric is well-proven to help relieve pressure, improve blood circulation, and reduce inflammation. It comes with a refreshingly simple ingredient list: curcumin, Bioperine, and black pepper. Bioperine helps the body absorb the main ingredient more easily, ensuring higher efficacy and quicker relief from pain. 

The supplement packs this in just the right dose and an easy-to-swallow size. It also comes at an impressively reasonable price. Just two pills a day can do wonders for the nerve and deep muscle pain caused by Fibromyalgia. 

Users also love its strong effect on bringing back flexibility in stiff joints. Thousands of users have reported a reduced inflammation and increased range of motion after just a week of consumption. 

Even better, taking a pill before starting the day prevents fibromyalgia pain from arising in the first place. Some users take it as a “before exercise pill” as it helps them engage in intensive activity and workouts without the risk of running into severe inflammation, tenderness, or stiffness afterward. 

Users also love that it can be taken without the risk of side effects or contraindications with another drug they are taking. However, being an all-natural solution, it is not as effective for dealing with severe and sharp pains caused by Fibromyalgia. You still may need a more potent supplement to get relief from debilitating pain or sudden flare-ups. 

2. Glucosamine 

The Hemp Oil Complex targets the neurological processes responsible for causing inflammation. The company promises that it uses non-genetically engineered hemp from nutrient-rich stalk and seed only. Hemp oil is popular for balancing the endocannabinoid system (ECS). The ECS is responsible for maintaining a wide variety of functions that often get affected by Fibromyalgia. 

These include sleeping, relaxing, and inflammation. Hemp Oil ensures that the sleep disruptions, signs of fatigue, and excessive inflammation are minimized. CBD oil helps with numbing down the pain by suppressing the pain signals sent to the brain. This approach makes it a great preemptive medicine that helps prevent instances of pain from arising in the first place. 

To see results, you need to take 2 pills every day, which start acting immediately. It allows users to carry out their daily responsibilities without facing worsening symptoms. CBD is believed to possess many anti-arthritic properties and can help with stiff and sore muscles as well. Other ingredients include TrueBroc and Broccoli, which help fight free radicals and promote antioxidant activity. This makes it especially useful as a post-workout treatment. 

Many studies find that antioxidants can prevent and reduce muscle soreness by fighting free radicals. Overall, it makes a more appropriate treatment for people who face inflammation on a daily basis and want something natural and chemical-free for intensive usage. 

3. Fish Oil plus Vitamin D3 by Nature’s Bounty, Contains Omega 3

Most patients with Fibromyalgia suffer from Vitamin D deficiency, which is essential in relieving chronic pain from the condition. Vitamin D modulates inflammatory and pain pathways, making it vital for healthy inflammatory responses. 

The powerful combination of Omega-3 and Vitamin D3 can quickly relieve deep muscle pain, joint stiffness, and body aches. The high concentration of fish oil in a potent form allows the supplement to reduce the symptoms caused by neuropathy and damaged nerves. 

Fish oil also has powerful anti-inflammatory properties and can help with muscle soreness and improve strength. It can be particularly helpful for people with a stiff back, neck, or shoulders, as it is well-known for bringing back a fuller range of motion by relaxing the muscles. 

If you suffer from fibromyalgia-related bone pain, the supplement can help you improve its symptoms as well. 

4. Garden of Life Wobenzym N Tablets

When it comes to Fibromyalgia, the severity and types of pain can be different in each case. This can make finding the perfect treatment a long process of trial and error. Trying out new supplements is not only frustrating but can also cost you a lot of money in the end. Garden Of Life offers the perfect all-rounder solution that targets a wide range of pain points. 

Whether you suffer from fatigue, nerve pain, bone weakness, or deep muscle pain, this simple supplement can help with all these problems. It comes with Wobenzym N as its main ingredient, clinically proven to reduce joint and muscle inflammation.

In most cases, it starts showing effects as soon as the first dose, making it perfect for unbearable pain. What makes it better than other all-natural supplements is the freedom of usage. 

Depending on the severity of your pain, you can take up to 3 pills a day without facing any risk of side effects. Unlike other supplements, you don’t need to take it every day to see results. The fast-action formula can be taken only when the pain arises. It also works amazingly for after exercise or other intensive activity inflammation. Its systemic enzyme formula helps overworked and strained muscles recover more quickly. 

As Fibromyalgia often causes stiffness in the neck and shoulder, it can help your muscles relax and soften up, resulting in a fuller range of motion. 

5. NOW Supplements, Acetyl-L Carnitine 500 mg

Acetyl L-carnitine is an incredible supplement for dealing with chronic fatigue and muscle stiffness caused by Fibromyalgia. It is a type of amino acid responsible for maintaining energy levels and allowing for better conversion of fatty acids into energy. 

If you suffer from chronic muscle pain throughout the day, taking one pill in the morning can reduce the severity of symptoms. It is especially helpful for individuals engaged in intensive and strenuous activity, as it helps with creating more energy. 

Also, its anti-inflammatory property also makes it an excellent post-workout and muscle recovery treatment. Studies have found that taking just 1-2 grams can help with reducing muscle soreness, release oxidative stress, and balance nervous system functioning. 

Thousands of fibromyalgia patients report lowered fatigue levels and needing fewer hours of sleep to feel refreshed. However, you may need to take up to 4 or 5 capsules a day for severe cases of pain. Acetyl L-carnitine is also a great mood stabilizer and can help with cognitive abilities as well. It can also help with improving concentration and bring clarity to thought processes. 

You may also benefit from it if you suffer from nerve pain caused by Fibromyalgia. Multiple studies have shown Acetyl L-carnitine to be helpful for neuropathy and nerve pain as well. The supplement is also fast-acting and shows improvement within the first 48 hours. 

6. New Chapter Zyflamend

This is another all-natural supplement that packs a punch. Chronic and acute pain sufferers swear by Zyflamend’s high potency, fast action, and superior bioavailability. It includes curcumin as its main ingredient, whose bioavailability is enhanced with the help of turmeric. 

Zyflamend is popular among users due to its ability to deliver improvements in just a few minutes. Other ingredients include rosemary, ginger, Holy Basil, organic green tea, and barberry. These work together to enhance each other’s potency and deliver a more powerful soothing effect. 

Also, it is one of the few supplements that can soothe more severe cases of inflammation and stiffness that are otherwise resolved with NSAIDs and other prescription medications. It is also free of any synthetic fillers, DLPA, animal enzymes, or harsh solvents. 

This makes it a much safer alternative for those non tolerant to oral pain reliefs and prescription medication. The formulation is fully Non-GMO and doesn’t come with any risk of addiction or long-term side effects. If you engage in persistent strenuous exercise, the manufacturer recommends that the pill’s potency can be enhanced with a tiny dose of ginger. 

While it is designed to relieve inflammation, soreness, and stiffness temporarily, users also report that it lowers their pain levels in the future. 

7. MegaRed Advanced 4 in 1

MegaRed is a more appropriate supplement for acute muscle pain and sudden flare-ups of Fibromyalgia. It is power-packed with high absorption krill oil and helps with joint comfort, heart health, and brain functioning. 

Krill oil is a well-known ingredient for its anti-arthritic and anti-inflammatory properties. This supplement makes it more bioavailable and potent, allowing it to deliver a more penetrative relief for deep muscle pain. It is a rich source of Omega-3s, the most recommended supplement for fatigue, muscle pain, and neuropathy. They have been shown to reduce muscle swelling and soreness and accelerate recovery after intensive activity. 

Most of the inflammation in Fibromyalgia is caused by poor blood circulation; omega-3s are also good at reducing tissue dehydration and helping improve blood circulation. When taken over the long run, 

MegaRed decreases the risk of developing inflammation in the future. It sets it apart from other supplements as it actually helps your body become healthier, rather than being a mere way to manage fibromyalgia symptoms. 

8. Calcium Magnesium & Zinc by Nature’s Bounty

The mineral supplement offers a well-rounded solution for a wide variety of fibromyalgia symptoms. Magnesium plays a vital role in muscle and nerve function. It can help release muscle soreness, cramping, and stiffness caused by Fibromyalgia. 

Patients with Fibromyalgia often test for magnesium and calcium deficiency, which can lead to higher pain levels. A higher magnesium intake is known to reduce the pain related to Fibromyalgia. Zinc is an antioxidant and comes with powerful anti-inflammatory properties; a higher intake can help you reduce swelling and soreness and speed up muscle recovery after intensive activity. 

This supplement packs the three potent minerals in an easy-to-swallow pill, making symptom management a breeze. These three work together to calm the nervous system and block the pain signals sent to the brain. Moreover, this combination is purposefully designed to help with mood and allows for a relaxer and calm brain activity. 

It also comes with Vitamin D3, which is more effectively absorbed with the help of the present calcium. Nature’s bounty is a well-known brand committed to delivering pure and safe supplements. The formula is fully non-GMO and gluten-free, making it perfect for non tolerant people and vegans. 

9. Doctor’s Best D-Ribose with Bioenergy Ribose

The Ribose supplement by Doctor’s Best is designed to help with stiffness and fatigue caused by Fibromyalgia. While it cannot help relieve inflammation and muscle pain, Ribose is a highly effective way to fight tight muscles throughout the body. It is especially helpful for patients engaged in extensive exercise or otherwise strenuous activity. The easy-to-swallow pills enable a faster replacement of the lost Adenosine Triphosphate (ATP) after a workout. 

ATP is responsible for energy production within the muscles and the heart. It ensures a higher energy reserve for a long day ahead. A 5g dose three times a day can help you prevent debilitating symptoms caused by the condition. 

Ribose is also directly related to lowering the severity of pain caused by tight and sore muscles. It is also gluten-free and non-GMO, making it fully vegan. 

However, it’s important to remember that the supplement can cause low blood sugar, making it unsuitable for people who have or are at risk of developing diabetes. 

10. Organic India Ashwagandha Herbal Supplement 

This Ashwagandha supplement by Organic India offers an all-natural and gentle solution to most fibromyalgia symptoms. The supplement is developed from one of the most praised plants in the Ayurvedic treatments. It is popular for its strength in fighting stress, fatigue, unhealthy sleep patterns, and calming the nerves. Ashwagandha is an adaptogen, a substance responsible for reducing physical and psychological stressors and mood swings. It works by blocking the pain signals from reaching the brain. 

Taking a pill at night can help you get undisturbed sleep. It’s also known to help with joint pain and stiffness caused by arthritis. It can help relieve inflammation, reduce lactic acid build-up, and speed up sore muscle recovery. It is also fully vegan, Non-GMO, and gluten-free.

11. Bulletproof’s Curcumin Max

Bulletproof offers a more holistic solution to your Fibromyalgia and covers the different aspects of pain, including fatigue, nerve pain, and tenderness. 

The pills are made with all-natural, plant-based ingredients that are well-known for their anti-inflammatory and stress-relieving properties. Boswellia, Stephania, Turmeric, and ginger work together to effectively fight inflammation while also suppressing the neurological process responsible for sudden spikes of pain. 

However, it is more appropriate as an after-therapy rather than a preemptive treatment for the inflammation to be caused ahead. 


This list only targets the most common symptoms and treatments of fibromyalgia. In the end, the best one will depend on the individual severity of and types of pain that you experience. Most supplements on the list are fully vegan, Non-GMO, and don’t carry any side effects.

However, it’s still important to consult your doctor and ensure that the ingredients don’t interfere with any other medication you are taking.

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